Quantitative Aspects of the Reaction between Insulin
نویسندگان
چکیده
The presence of insulin-binding antibodies in the serums of insulin-treated subjects has been reported previously (1). With I"ll-labeled insulin it has been shown that the antigen-antibody complexes do not precipitate, that the binding of insulin to antibody is a reversible process, and that, at constant antibody concentration, the ratio of bound insulin to free insulin is an inverse function of the concentration of insulin (1). In the present studies, experimental data on the reaction between insulin and insulin-binding antibody are tested against several theoretical models. The results are most compatible with a model composed of a univalent insulin reacting with two distinctly different orders of antibody sites. Data for equilibrium constants, forward and reverse velocity constants and various thermodynamic constants are presented in terms of the model chosen.
منابع مشابه
Association between Insulin–Like Growth Factor I Polymorphism and Early Growth Traits in Iranian Zandi Sheep, Found Polymerase Chain Reaction Restriction Fragment Length Polymorphism (PCR-RFLP)
Early growth traits in sheep are economically important. Breeding for these traits has been shown to be problematic using quantitative genetic methods, particularly in native sheep herds. Molecular genetics is useful for sheep breeding. The gene for insulin-like growth factor 1 (IGF1) is one of the important candidate genes known for ovine early growth traits. The aim of this study was to inves...
متن کاملQuantitative Studies on the Neutralization Reaction between African Horse-sickness Virus and Antiserum
متن کامل
Serum Adiponectin in Women with Gestational Diabetes
Background &Objective: Adiponectin is an adipose tissue adipokin that may contribute to obesity and insulin resistantance. The aim of this study was to evaluate the associations between serum concentrations of adiponectin and insulin resistance in gestational diabetes (GDM).Materials & Methods: Serum adiponectin levels, fasting blood sugar (FBS), glycated hemoglobin (HbA1C), insulin levels and ...
متن کاملThe Relationship between Antioxidants Consumption and Insulin Resistance/Insulin Sensitivity in Type 2 Diabetes without and with Coronary Stenosis: A Case-Control Study
Background: Type 2 diabetes (T2D) is known as a common chronic metabolic disease worldwide. Coronary artery diseases are one of the hazardous disorders in diabetic patients. The current study aimed to investigate the relationship between dietary antioxidants intake with insulin resistance and insulin sensitivity among T2D without and with coronary stenosis (CS). Methods: This case-control study...
متن کاملDifferentiation of Mesenchymal Stem Cell toward the Insulin-like Cells with Lentivirus Vector Mir-375
Background & Objective: Type1 diabetes is characterized by autoimmune destruction of pancreatic β cells, leading to reduced insulin secretion. Differentiation of mesenchymal stem cells (MSCs) into β-like cells offers new ways of diabetes treatment. MSCs can be insulated from the human umbilical cord tissue and differentiate into insulin-producing cells. Material & Methods: Human um...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013